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目的 :观察基因重组人生长激素 (r-hGH)治疗儿童垂体性生长激素缺乏症 (GHD)的远期疗效。方法 :采用追踪调查方法观察了48名特发性生长激素缺乏症病人 ,经十年远期身高随访。结果 :生长激素 (GH)治疗≤ 3月组 ,远期身高标准差积分 (SDS)较治疗前无明显变化(P >0 0 5) ;治疗 3月～ 1 5年组 ,远期身高SDS较治疗前明显增加 ,差异显著 (P <0 0 5) ;治疗≥ 1 5年组 ,远期身高SDS较治疗前显著增加(P <0 0 1 )。结论 :GH治疗效果与治疗持续时间有关 ,≤ 3个月远期疗效不明显 ,治疗时间越长 ,效果越好。
Objective: To observe the long-term efficacy of recombinant human growth hormone (r-hGH) in the treatment of pituitary growth hormone deficiency (GHD) in children. Methods: Forty-eight patients with idiopathic growth hormone deficiency were observed by follow-up survey and followed up for ten years. Results: There was no significant difference in long-term height standard deviation integral (SDS) between the treatment group and the control group (P> 0.05) Significantly increased before treatment, the difference was significant (P <0 05); treatment ≥ 15 years group, long-term height SDS was significantly increased (P <0.01). Conclusion: The therapeutic effect of GH is related to the duration of treatment. Long-term curative effect is not obvious for ≤ 3 months. The longer the treatment time, the better the effect.