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本研究探讨三七-红花有效组分复方对于心肌梗死大鼠的心肌保护作用.在结扎冠状动脉左前降支后,给大鼠连续7天口服给予三七-红花有效组分复方.三七-红花有效组分复方能够阻止心肌梗死引起的病理生理改变,显著降低血浆中肌酸激酶MB同工酶、乳酸脱氢酶以及天冬氨酸转氨酶三种心肌酶的表达;深入研究表明三七-红花有效组分复方能够减少血浆中肿瘤坏死因子-α、白细胞介质-6以及白细胞介质-1β三种炎症因子的产生.此外,三七-红花有效组分复方能降低梗塞组织中caspase-3 mRNA的表达.研究结果表明,三七-红花有效组分复方通过抗炎和抗凋亡发挥对心肌梗死大鼠的保护作用.“,”In this study,the cardioprotective mechanism of the combination of notoginseng total saponins and safflower total flavonoids (CNS) was investigated due to its excellently efficacy against myocardial infarction (MI) in rats.After the left anterior descending coronary artery (LADCA) ligation,rats were orally administered with CNS for 7 consecutive days.CNS prevented MI-induced pathophysiological changes and significantly decreased plasma levels of myocardial enzymes,including creatine kinase MB isoenzyme (CK-MB),lactate dehydrogenase (LDH) and aspartate aminotransferase (AST).Further investigation revealed that CNS attenuated the production of inflammatory factors in plasma,including tumor necrosis factor-alpha (TNF-α),interleukin-6 (IL-6) and interleukin-1β (IL-1β).Moreover,CNS treatment decreased the expression of caspase-3 at the mRNA level in infarct tissue.Our findings demonstrated that the anti-inflammatory and anti-apoptotic properties of CNS might confer its cardioprotection against MI in rats.