论文部分内容阅读
A large number of sesquiterpene quinone/hydroquinone natural products including(+)-ent-chromazonarol have been isolated and received great attention from the synthetic community.Herein,we report a nature-inspired concise synthesis of(+)-ent-chromazonarol in 4 steps from a readily available starting material.The synthesis relied on a Lewis acid mediated cyclization which correctly installed two vicinal stereocenters in one step.This highly efficient synthetic route allows us to further prepare natural product congeners for further biological studies.