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对40例膀胱移行上皮细胞癌病人测定血清和尿β_2M,并对其中33例肿瘤石蜡包埋标本作流式细胞分析。β_2M在肿瘤病人血清中阳性率为65％,尿中阳性率为52.5％。β_2M随临床分期不同而有一定的差异;肿瘤细胞DNA倍体不同,其相应的β_2M水平也有不同。认为β_2M可作为膀胱移行上皮癌的非特异性肿瘤标记。
Serum and urinary β_2M levels were measured in 40 cases of transitional cell carcinoma of the bladder and 33 cases of tumor paraffin embedded specimens were analyzed by flow cytometry. The positive rate of β_2M in the serum of tumor patients was 65%, and the positive rate in urine was 52.5%. β_2M has some differences with the clinical stage; DNA ploidy of different tumor cells, the corresponding β_2M level is also different. Β 2 M is considered as a nonspecific tumor marker for bladder transitional epithelial carcinoma.