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目的研究巨细胞病毒(CMV)感染患者治疗前后外周血染色体着丝粒点(Cd)变异率的变化,为优生优育积累实验依据。方法选择早期自然流产且有CMV(PCR检测)感染的孕妇22例,取静脉血以同步银染法检测染色体Cd变异率,然后采用抗病毒和免疫调节对患者进行治疗,当CMV转阴性时和转阴性6个月后采血进行染色体Cd分析,所得数据通过统计学处理分析CMV感染和治疗后血液染色体Cd畸变情况,并观察其妊娠结局。结果22例CMV感染患者血液Cd畸变率为0.76±0.14/细胞,而经抗病毒药物治疗后畸变率为0.28±0.04/细胞,二者比较具有显著性差异(P<0.0001)。结论抗体病毒治疗可降低Cd畸变率,这对健康妊娠意义重大。
Objective To study the variation of chromosome centromere (Cd) mutation in peripheral blood of patients with cytomegalovirus (CMV) infection before and after treatment, and to accumulate experimental evidence for prenatal and postnatal care. Methods Twenty-two pregnant women with early spontaneous abortion and infection with CMV (PCR test) were selected. Venous blood was taken to detect chromosomal Cd mutation rate by synchronous silver staining. The patients were then treated with antiviral and immunomodulatory drugs. When CMV negative and Negative blood samples were collected six months later for chromosomal analysis of Cd. The data were analyzed by statistical analysis of CMV infection and post-treatment blood chromosomal Cd distortion and observed the pregnancy outcome. Results The blood CD aberration rate was 0.76 ± 0.14 / cell in 22 patients with CMV infection and 0.28 ± 0.04 / cell after antiviral therapy. The difference was significant (P <0.0001). Conclusion Antibody virus treatment can reduce the rate of Cd distortion, which is of great significance to healthy pregnancy.