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应用薄层色谱扫描法，动态观察了实验性甲低大鼠脑，红细胞膜神经磷脂（ＳＭ）／磷脂酰胆碱（ＰＣ）分子比变化，结果表明持续用甲基硫脲嘧啶（ＭＴＵ）和脑发育临界期后停ＭＴＵ组，ＳＭ／ＰＣ分子比明显升高（Ｐ＜０．０５）。提示脑发育临界期内甲状腺激素缺乏，可导致生物膜的明显老化，膜磷脂分布破坏造成一系列结构和功能的改变，进而使中枢神经系统发育异常和功能障碍。
The changes of the molecular ratio of SM / PC in experimental hypothyroid rats were observed by thin layer chromatography (TLC), and the results showed that the sustained release of methylthiouracil (MTU) and After the critical period of brain development, the MTU group and SM / PC molecular ratio were significantly increased (P <0.05). Suggesting that lack of thyroid hormone in the critical stage of brain development can lead to significant aging of the biofilm and disruption of membrane phospholipids resulting in a series of structural and functional changes that lead to abnormalities in the central nervous system and dysfunction.