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[目的]研究温州市居民高尿酸血症(HUA)的流行特征。[方法]采用多阶段随机抽样方法抽取温州市瑞安、瓯海两个区3 502例≥35岁常住居民进行面对面问卷调查、体格检查及实验室检查。测量调查对象的身高、体重、血压,测定空腹血糖、血总胆固醇、三酰甘油、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇、尿酸。[结果]温州市居民尿酸均值为(260.25±93.21)μmol/L,高尿酸血症率为7.47%,男、女分别为10.78%、4.93%;代谢综合征(MS)的患病率为17.90%。HUA组MS患病率为34.62%,尿酸正常组为16.55%(P<0.01)。HUA组MS组分高血压、高血糖、低高密度脂蛋白、高三酰甘油、肥胖比例分别为62.31%、26.15%、13.46%、67.31%、46.92%,明显高于尿酸正常组。多因素Logistic回归分析显示,HUA与男性、饮酒、年龄(>65岁)、肥胖、高低密度脂蛋白、高三酰甘油密切相关。[结论]温州市HUA患病率为7.47%,HUA与MS的主要组分肥胖、高低密度脂蛋白、高甘油三酯密切相关,做好HUA早期干预至关重要。
[Objective] To study the prevalence of hyperuricemia (HUA) in Wenzhou residents. [Methods] A total of 3 502 permanent residents aged 35 years or older in two districts of Ruian and Ouhai in Wenzhou City were sampled for face-to-face questionnaire, physical examination and laboratory examination using a multi-stage random sampling method. Subjects were surveyed for height, weight, blood pressure, fasting blood glucose, blood total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and uric acid. [Results] The average uric acid in Wenzhou was (260.25 ± 93.21) μmol / L, the rate of hyperuricemia was 7.47%, and the male and female were 10.78% and 4.93% respectively. The prevalence of metabolic syndrome (MS) was 17.90 %. The prevalence of MS was 34.62% in HUA group and 16.55% in normal uric acid group (P <0.01). The percentage of hypertension, hyperglycemia, low density lipoprotein, high triglyceride and obesity of MS group in HUA group were 62.31%, 26.15%, 13.46%, 67.31% and 46.92%, respectively, which were significantly higher than those in normal uric acid group. Multivariate Logistic regression analysis showed that HUA was closely related to male, alcohol consumption, age (> 65 years), obesity, high and low density lipoprotein, and high triglyceride. [Conclusion] The prevalence of HUA in Wenzhou is 7.47%. HUA is closely related to obesity, high-density lipoprotein, high-density lipoprotein and high triglyceride in MS. Early intervention with HUA is very important.