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目的:观察 P_(53)及 nm23基因产物在肺癌中的表达及其与肺癌预后的关系。方法:LSAB 免疫组化法。结果:肺腺癌组 P_(53)表达与淋巴结转移呈正相关(P<0.05);肺鳞癌 nm23基因表达与淋巴结转移呈负相关(P<0.05),nm23表达腺癌组高于鳞癌组(P<0.05)。结论:对 P_(53)及 nm23基因产物的检测可作为对肺腺癌、鳞癌淋巴结转移趋势预测的一个参考指标。
Objective: To observe the expression of P53 and nm23 gene products in lung cancer and its relationship with prognosis of lung cancer. Methods: LSAB immunohistochemistry. Results: The expression of P_53 in lung adenocarcinoma was positively correlated with lymph node metastasis (P<0.05). The expression of nm23 in lung squamous cell carcinoma was negatively correlated with lymph node metastasis (P<0.05). The nm23-expressing adenocarcinoma was higher than that in squamous cell carcinoma. (P<0.05). Conclusion: The detection of P_(53) and nm23 gene products can be used as a reference index for predicting the lymph node metastasis of lung adenocarcinoma and squamous cell carcinoma.