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目的探讨胰岛素样生长因子Ｉ（ＩＧＦⅠ）及胰岛素（Ｉｎｓ）与胎儿宫内发育迟缓（ＩＵＧＲ）发病的关系。方法应用放射免疫分析法和酶联免疫吸附试验，分别测定１７例ＩＵＧＲ患儿、孕妇（ＩＵＧＲ组）血清及羊水中Ｉｎｓ和ＩＧＦⅠ水平，同期住院的正常晚期妊娠妇女３８例（正常妊娠组）作为对照。结果（１）ＩＵＧＲ组孕妇血清ＩＧＦⅠ为１１７．２９μｇ／Ｌ，低于正常妊娠组的２０７．０７μｇ／Ｌ，两者比较，差异有极显著性（Ｐ＜０．００２）；ＩＵＧＲ组脐血清ＩＧＦⅠ为１６．７３μｇ／Ｌ，低于正常妊娠组的４４．８９μｇ／Ｌ，两者比较，差异有极显著性（Ｐ＜０．００１）。（２）ＩＵＧＲ组孕妇血清Ｉｎｓ为１２．１８ｍＩＵ／Ｌ，高于正常妊娠组的７．１３ｍＩＵ／Ｌ，两者比较，差异无显著性（Ｐ＞０．０５）。结论ＩＧＦⅠ及Ｉｎｓ可能参与ＩＵＧＲ的病理生理过程。
Objective To investigate the relationship between insulin-like growth factor-I (IGF-Ⅰ) and insulin (Insu) and intrauterine growth retardation (IUGR). Methods Radioimmunoassay and enzyme-linked immunosorbent assay were used to detect the levels of Ins and IGF-Ⅰ in serum and amniotic fluid of 17 IUGR children and pregnant women (IUGR group) respectively. 38 normal pregnant women (normal pregnancy group) )as comparison. Results (1) The serum IGFⅠin IUGR group was 117.29μg / L, which was lower than 207.07μg / L in normal pregnancy group, the difference was significant (P <0.002) Serum IGF Ⅰ 16.73μg / L, lower than the normal pregnancy group 44.89μg / L, the two compared, the difference was significant (P <0.001). (2) The serum Ins of IUGR group was 12.18mIU / L, which was higher than that of the normal pregnancy group (7.13mIU / L). There was no significant difference between the two groups (P> 0.05). Conclusion IGF Ⅰ and Ins may participate in the pathophysiology of IUGR.