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目的:探讨高血压患者体内高敏C-反应蛋白(hs-CRP)、内皮素-1(ET-1)与脉压差三者之间的关系。方法:按标准方法测定脉压差,通过免疫散射比浊法检测其血中hs-CRP、放射免疫法测定ET-1的含量,分析三者的关系。结果:在校正了平均血压及其他相关因素后,线性回归分析表明,脉压差与hs-CRP、ET-1均呈正相关。结论:高血压患者的脉压差与hs-CRP、ET-1密切相关,推测炎症可能是增加血压变异性的一个独立危险因素。
Objective: To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP), endothelin-1 (ET-1) and pulse pressure difference in patients with hypertension. Methods: The blood pressure hs-CRP was measured by standard immunostaining turbidimetry and the content of ET-1 by radioimmunoassay. The relationship between the three was analyzed. Results: After adjusting for mean blood pressure and other related factors, linear regression analysis showed that pulse pressure was positively correlated with hs-CRP and ET-1. Conclusion: The pulse pressure difference is closely related to hs-CRP and ET-1 in hypertensive patients. It is speculated that inflammation may be an independent risk factor for increasing blood pressure variability.