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目的：评价鸦胆子油－碘油“夹馅”栓塞法、瘤内注射乙醇与免疫因子联合介入治疗中晚期肝癌的临床疗效。方法：３７例失去手术机会的中晚期肝癌患者，分为两组：Ａ组交替做经肝动脉鸦胆子油－碘油－抗癌药“夹馅”法栓塞化疗（ＴＡＥ）及经皮无水乙醇癌灶内注射（ＰＥＩ），并联合局部应用免疫因子介入治疗；Ｂ组单纯用ＴＡＥ治疗。结果：Ａ组和Ｂ组的显效率、有效率、１年生存率分别为４７％和１０％、１００％和９０％、７６％和３０％，其差异有显著性；而两组的毒副反应无明显差异。Ａ组１７例患者中有７例获手术切除。结论：ＴＡＥ＋ＰＥＩ＋局部注射免疫因子的综合介入疗法，可能成为治疗中晚期ＨＣＣ的一种新方法。
OBJECTIVE: To evaluate the clinical efficacy of Brucea javanica oil-lipiodol embolization, intratumoral injection of ethanol and immune factors in the interventional treatment of advanced hepatocellular carcinoma. Methods: Thirty-seven patients with advanced liver cancer who had lost surgery were divided into two groups: Group A was treated with alternating hepatobiliary bile oil-lipiodol-anticancer drug embolization (TAE) and percutaneous anhydrous Ethanol cancer intratumoral injection (PEI) was combined with local application of immunological interventions; Group B was treated with TAE alone. Results: The significant, effective and one-year survival rates in groups A and B were 47% and 10%, 100% and 90%, 76% and 30%, respectively. The difference was significant. No significant difference in response. Seven of the 17 patients in group A were surgically removed. Conclusion: The comprehensive interventional therapy of TAE+PEI+local injection of immune factors may be a new method for the treatment of advanced HCC.