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目的探讨炼焦工人淋巴细胞微核率与血浆苯并（ａ）芘浓度的关系。方法分别抽取炼焦和非炼焦职工各１００名进行流行病学调查，对每一位对象进行微核检测计数和血浆苯并（ａ）芘浓度的检测，并检测空气中苯并（ａ）芘浓度。结果炼焦工人与非炼焦职工血浆苯并（ａ）芘的浓度差异有非常显著性，且人体苯并（ａ）芘浓度与空气中苯并（ａ）芘浓度有相关性。微核阳性率和微核细胞率：炼焦工人分别为６０％和１．７９‰，非炼焦职工分别为２９％和１．０１‰，两者差异有非常显著性。以不同血浆浓度为暴露指标分级，显示微核阳性率与血浆苯并（ａ）芘浓度存在剂量反应关系。多因素分析显示，对微核阳性率起作用的因素依次为血浆苯并（ａ）芘浓度、经济水平、生活是否规律和吸烟。结论血浆苯并（ａ）芘的蓄积是导致微核形成的主要因素。对炼焦工人进行微核检测，可反映炼焦作业对机体早期的危害。
Objective To investigate the relationship between the micronucleus frequency of coking workers and the concentration of benzo (a) pyrene in coking workers. Methods A total of 100 coking and non-coking workers were recruited for epidemiological investigation. The micronucleus test counts and the plasma benzo (a) pyrene concentration were measured in each subject. The concentrations of benzo (a) pyrene in the air . Results There was a significant difference in the concentration of benzo (a) pyrene between coking workers and non-coking workers, and the concentration of benzo (a) pyrene in the human body was correlated with the concentration of benzo (a) pyrene in the air. The positive rate of micronuclei and the rate of micronucleated cells were 60% and 1.79% for coking workers and 29% and 1.01% for non-coking workers, respectively. There was a significant difference between the two. Different plasma concentrations of exposure indicators grading, showing the positive rate of micronuclei and plasma benzo (a) pyrene concentration dose-response relationship. Multivariate analysis showed that the factors influencing the positive rate of micronuclei were as follows: the concentration of benzo (a) pyrene, the economic level, the law of life and smoking. Conclusion The accumulation of benzo (a) pyrene in plasma is the main factor leading to the formation of micronuclei. Micronucleus testing of coking workers can reflect the early coking operations on the body hazards.