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胃肠道癌手术加腹腔内温热灌注化疗(IPIH)能有效减少和预防术后复发,提高肿瘤的治疗效果.我院自1996年1月～1999年1月对22例消化道癌患者用42℃～43℃的5-氟脲嘧啶(5—Fu)、丝裂霉素(MMC)、顺铂(DDP)盐水作术中、术后腹腔内温热灌注联合化疗,取得良好效果,报告如下.1 临床资料1.1 一般资料 本组共22例,其中男17例,女5例;最大年龄68岁,最小29岁.其中胃癌8例,按TNM分期,Ⅱ期5例、Ⅲ期3例,行胃癌根治术者6例、姑息切除2例;结肠癌11例,直肠癌3例,按Dukes分期法,C期9例、D期5例,行根治切除者10例、姑息切除4例.另设16例作单纯手术对照组,男13例,女3例;最大年龄67岁,最小24岁.其中胃癌5例、结肠癌9例、直肠癌2例,临床分期及手术方法同治疗组.
Gastrointestinal cancer surgery plus intraperitoneal hyperthermic perfusion chemotherapy (IPIH) can effectively reduce and prevent postoperative recurrence and improve the therapeutic effect of tumors. Our hospital has used 22 cases of gastrointestinal cancer patients from January 1996 to January 1999. 42-43 °C 5-fluorouracil (5-Fu), mitomycin (MMC), cisplatin (DDP) saline for intraoperative and postoperative intraperitoneal hyperthermic perfusion combined with chemotherapy, achieved good results, report As follows. 1 Clinical data 1.1 General information The group of 22 cases, including 17 males and 5 females; maximum age 68 years, minimum 29 years old. Among them, 8 cases of gastric cancer, according to TNM stage, II stage 5 cases, III stage 3 cases. There were 6 cases of radical gastrectomy and 2 cases of palliative resection. 11 cases of colon cancer and 3 cases of rectal cancer. According to the Dukes staging method, there were 9 cases of C stage and 5 cases of D stage. There were 10 cases of radical resection and 4 cases of palliative resection. 16 patients were included in the simple surgical control group. There were 13 males and 3 females; the maximum age was 67 years and the minimum was 24 years. There were 5 cases of gastric cancer, 9 cases of colon cancer, and 2 cases of rectal cancer. Clinical staging and surgical treatment were the same. group.