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目的探讨老年高血压病患者血清瘦素(Leptin)与颈动脉内膜中层厚度(IMT)的关系。方法选取60岁以上老年高血压病患者111例为研究对象,进行血压、血糖、血脂、血清瘦素的测定并测定腰臀比(WHR)计算体质量指数(BMI),使用高分辨率超声检测双侧颈动脉IMT,把研究对象按IMT分为两组:IMT<1.0mm(n=54)组和IMT≥1.0mm(n=57)组,比较两组的差异,并进行相关性分析。结果IMT≥1.0mm组年龄、体质量、BMI、SBP、WHR、Leptin、TC、TG、HDL-C、LDL-C均显著高于IMT<1.0mm组,leptin与IMT具有相关性(r=0.85,P<0.01)。结论老年高血压病患者leptin与IMT明显相关。
Objective To investigate the relationship between serum leptin and carotid intima-media thickness (IMT) in elderly patients with essential hypertension. Methods A total of 111 elderly hypertensive patients over the age of 60 were selected as subjects. The body mass index (BMI) was calculated by measuring blood pressure, blood glucose, blood lipid, serum leptin and waist-hip ratio (WHR). High-resolution ultrasound Bilateral carotid IMT was divided into two groups according to IMT: IMT <1.0mm (n = 54) group and IMT≥1.0mm (n = 57) group. The differences between the two groups were compared and analyzed. Results The age, body mass, BMI, SBP, WHR, Leptin, TC, TG, HDL-C and LDL-C in IMT≥1.0mm group were significantly higher than those in IMT≤1.0mm group , P <0.01). Conclusion There is a significant correlation between leptin and IMT in elderly patients with hypertension.