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目的:探讨和研究乙型肝炎患者乙型肝炎病毒(HBV)DNA复制水平与丙氨酸氨基转移酶(ALT)水平之间的关系,为临床中乙肝患者的诊治提供参考。方法:对240例慢性乙型肝炎患者采用荧光标记定量PCR方法测定血清HBV-DNA含量,采用全自动生化分析仪测定血清ALT水平,比较和分析HBV-DNA含量与ALT水平之间的关系。结果:慢性乙肝轻、中、重度患者的HBV-DNA含量三组之间差异有统计学意义(p<0.01),肝脏的损害程度与HBV-DNA含量之间具有一定的关联,等级相关系数为0.162(P=0.012);ALT水平也与HBV-DNA载量之间存在关联,等级相关系数为0.371(P<0.0001)。结论:肝损伤程度与HBV-DNA含量有显著相关性;同时血清ALT水平与HBV-DNA含量呈正相关。检测血清中的HBV-DNA含量和ALT水平为指导乙肝患者HBV感染、复制、传染性的判断、治疗方案的选择和疗效评定提供有一定的依据。
Objective: To investigate and study the relationship between hepatitis B virus (HBV) DNA replication level and alanine aminotransferase (ALT) level in hepatitis B patients and provide reference for the diagnosis and treatment of hepatitis B patients in clinic. Methods: Serum HBV-DNA levels were measured by fluorescence quantitative PCR in 240 patients with chronic hepatitis B, serum ALT levels were measured by automatic biochemical analyzer, and the relationship between HBV-DNA levels and ALT levels was compared and analyzed. Results: The levels of HBV DNA in patients with mild, moderate and severe chronic hepatitis B were significantly different (p <0.01). The degree of liver damage was correlated with the level of HBV DNA. The level of correlation coefficient 0.162 (P = 0.012). There was also a correlation between ALT level and HBV DNA load with a rank correlation coefficient of 0.371 (P <0.0001). Conclusion: There is a significant correlation between the degree of liver injury and the content of HBV-DNA. Meanwhile, the level of serum ALT is positively correlated with the content of HBV-DNA. Detection of serum HBV-DNA content and ALT levels for the guidance of hepatitis B patients with HBV infection, replication, infectious judgment, treatment options and efficacy evaluation provide a basis.