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我国民间曾用楝树皮水煮剂驱除蛔虫,效果良好。为此对四川楝树Melia toosendan和广西楝树M.azedarach进行了化学成分和药理作用的研究。有人从上述品种中均分出驱蛔虫有效成分川楝素,驱蛔虫效果好,毒性小,已用于临床,并测定了结构。本文报道其中另一活性成分,因其分子量(M~+,574)与川楝紊相同,故名异川楝素,为无色细针状晶体,熔点270～273℃(分解)。该品红外光谱有羟基、六员环酮(1705cm~(-1))和乙酰氧基(1730,12 70和1230cm~(-1)),还有呋喃杂环(3130,1500和878cm~(-1))等与川楝素相同的功能基。紫外光谱和氢核磁共振谱表明为β-单取代呋喃(~1HNMR δ7.35,7.30和6.24)。
People in China have used eucalyptus bark cooking agents to drive out locusts, and the effect is good. For this purpose, the chemical composition and pharmacological effects of Melia toosendan and Guangxi M.azedarach were studied. Some people from the above-mentioned species are divided into the driving force of the effective component of Ascaris Chuanxiong, driving insects is effective, less toxic, has been used in clinical, and measured the structure. This article reported that the other active ingredient, because of its molecular weight (M ~ +, 574) and Chuanxiong turbidity, the name isoprenaline, a colorless needle-like crystals, melting point 270 ~ 273 °C (decomposition). The infrared spectrum of the product is hydroxyl, six-membered ketone (1705cm -1) and acetoxy (1730, 1270, and 1230cm -1), and furan heterocycle (3130, 1500, and 878cm - -1)) and other functional groups that are the same as those of Saponin. The UV and HNMR spectra showed β-monosubstituted furans (~1H NMR δ 7.35, 7.30 and 6.24).