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本文应用广泛性脑梗塞患者分离的、经免疫荧光与免疫酶染色证明为钩端螺旋体（简称钩体）L型的稳定株并以钩体原型为对照，感染豚鼠，感染次日两组动物体温均升高，感染原型组4／5从血液分离出钩体，L型组3／5分离出L型。2月后处死两组豚鼠取血分离，原型组钩体已从血中消失，而L型仍有3只分离出L型。病理切片证明两组病变主要为心、骨骼肌、肺、眼的间质性失，并有肝窦、小动脉狭窄，肺出血明显，脊髓前角神经细胞变性，原型组中有1只在肾曲小管中见有L型。结果表明，钩体L型稳定株可长期在血中存活能引起眼、神经后发症。原型感染后从血中迅速消失，但L型在肾中存在。说明原型在体内可转变为L型，并从尿中排出，成为一重要的传染源。
In this paper, isolated from patients with extensive cerebral infarction, immunofluorescence and immunoenzymatic staining showed that the leptospira L type stable strain and the hook prototype as control, infected guinea pigs infected the next day two groups of animals body temperature Were elevated, 4/5 infection prototype group isolated from the blood leptospira, L-type group 3/5 isolated L-type. Two groups of guinea pigs were sacrificed after 2 months, the prototype hook body has disappeared from the blood, while L type still has 3 L type. Pathological sections showed that the lesions of the two groups were mainly interstitial loss of heart, skeletal muscle, lung and eye with hepatic sinusoid and arteriole stenosis, obvious pulmonary hemorrhage and degeneration of neurons in spinal cord anterior horn. Tracheal see L type. The results showed that L-shaped Strain could survive long-term in the blood and cause post-ophthalmic and post-neurological complications. The prototype rapidly disappears from the bloodstream after infection, but the L-form is present in the kidneys. That the prototype can be transformed into L-type body, and excreted from the urine, has become an important source of infection.