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当小白鼠处于禁食、患糖尿病、置于环境温度为37℃、注射高血糖素、二丁基环状AMP或考的松时,它们对鼠疫菌鼠毒素精制品的易感性明显降低。对比之下,对高糖脱脂食物喂食的小白鼠以及放置在5℃或17℃温度下的小白鼠,鼠毒素的致死性明显增强。同对照相比,用鼠毒素攻击的小白鼠中,肾上腺素并不能引起血糖升高或血浆游离脂肪酸含量增加。这些结果证实机体降温是致死主要决定因素的一种作用方式。
When mice were fasted, diabetic, and exposed to ambient temperature of 37 ° C, injecting glucagon, dibutyl cyclic AMP or cortisone, their susceptibility to the plague virulent toxin preparations was significantly reduced. In contrast, the lethality of the toxins was significantly enhanced in mice fed with high-sugar defatted foods and in mice placed at temperatures of 5 ° C or 17 ° C. Adrenaline did not cause elevated blood glucose or increased plasma free fatty acid levels in mice challenged with the toxin compared with controls. These results confirm that cooling of the body is a mode of action that is a major determinant of lethality.