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目的:观察加味逍遥散联合西药治疗肝郁脾虚证肝病患者的临床疗效。方法:选取144例肝郁脾虚证肝病患者,使用加味逍遥散、维生素B、维生素C、维生素E、还原性谷胱甘肽、肌苷片治疗,2月为1疗程,治疗1疗程后,比较治疗前后的临床症状积分、生化指标的变化。结果:用药1疗程后,患者胸胁少腹胀痛、疲乏、嗳气、纳呆、烦躁的临床症状积分均较用药前降低(P<0.05)。患者的谷丙转氨酶(ALT)、总胆汁酸(TBA)均较用药前下降(P<0.05),白蛋白(Alb)、胆碱酯酶(CHE)活力均较用药前上升(P<0.05)。结论:加味逍遥散联合西药可有效减轻肝郁脾虚证肝病患者的临床症状,减轻其肝损伤状态并促进肝细胞的生成及自我修复,具有良好的疗效,对改善患者的生活质量具有重要意义。
Objective: To observe the clinical effects of Jiawei Xiaoyaosan combined with western medicine in the treatment of liver disease with liver depression and spleen deficiency syndrome. Methods: One hundred and forty-four cases of liver disease with liver-qi and spleen deficiency syndrome were selected and treated with Modified Xiaoyao San, Vitamin B, Vitamin C, Vitamin E, Reduced glutathione and inosine tablets. Clinical symptoms before and after treatment points, biochemical changes. Results: After 1 course of treatment, the clinical symptom scores of chest weakness, abdominal pain, fatigue, belching, appetite and irritability were all lower than those before treatment (P <0.05). The levels of ALT and TBA were significantly lower than those before treatment (P <0.05), and those of albumin (Alb) and cholinesterase (CHE) were higher than those before treatment (P <0.05) . Conclusion: Jiawei Xiaoyaosan combined with western medicine can effectively reduce the clinical symptoms of liver disease due to liver depression and spleen deficiency, reduce the liver injury and promote the generation and self-repair of hepatocytes, which has a good curative effect and is of great significance to improve patients’ quality of life.