论文部分内容阅读
艾利希氏在本世纪之初最先介绍化疗指数的概念,即最大耐受量与最小有效量的比数。耐受量表示向宿主作用的强度,而有效量表示向病原体作用的强度。比数愈大愈安全,所以也可视为安全比数或安全系数。后来这一概念扩充到化疗药以外的药物,最小有效量的含义已经不是向病原体作用所能概括,于是统称治疗指数。亦有治疗宽度和安全范围等说法。各家定义虽不尽相同,而且也有所发展,但根本目的仍是用以表示药物的安全度。计有:最大耐量与最小效量之比;最小中毒量与
Ehrlich first introduced the concept of chemotherapy index at the beginning of this century, the ratio of the maximum to the minimum effective dose. Tolerance means the intensity of action on the host and the effective amount means the intensity of action on the pathogen. The greater the number of the more secure, it can also be regarded as a safe ratio or safety factor. Later, the concept extended to drugs other than chemotherapy drugs, the minimum effective amount of meaning is not to the role of pathogens can be summarized, so collectively referred to the treatment index. There are also treatment width and safety range and other statements. Although the definition of each is not the same, but also developed, but the fundamental purpose is still used to indicate the safety of drugs. There are: the ratio of maximum to minimum dose; the minimum amount of poisoning