【摘 要】
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A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the react
【机 构】
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Department of Chemistry, Semnan University,
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
A cost-effective, highly useful and eco-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the reaction of various aldehydes, malononitrile and phenylhydrazine or 4-phenylthiosemicarbazide in PEG-400 and water at room temperature under ultrasound irradiation. Utilization of green solvents without a catalyst makes this methodology very interesting from economic and environmental perspectives. This method provides several advantages such as operational simplicity, use of accessible and economical starting materials and reduced environmental consequences.
A cost-effective, highly useful and highly-friendly procedure for the one-pot synthesis of highly substituted pyrazole derivatives has been developed via the reaction of various aldehydes, malononitrile and phenylhydrazine or 4-phenylthiosemicarbazide in PEG-400 and water at room temperature under ultrasound irradiation. Utilization of green solvents without a catalyst makes this method very interesting from economic and environmental perspectives. This method provides several advantages such as operational simplicity, use of accessible and economical starting materials and reduced environmental consequences.
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