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为探讨腺苷在低氧性肺动脉高压中扩血管作用的量效关系，采用静脉匀速滴注腺苷的方法观察８只低氧性肺动脉高压犬的血流动力学变化。结果：腺苷能明显降低模型犬的体、肺循环压力及体、肺循环阻力，且与剂量呈直线负相关（ｒ＝－０．９７０～－０．９９４，Ｐ＜０．０５）。腺苷剂量在１００～２００μｇ／（ｋｇ·ｍｉｎ）时，肺循环收缩压及阻力的降低百分比（－１１．０％±４．２％～－２７．７±１４．８％、－１８．８％±８．０５％～－２９．８％±１４．４６％）明显高于体循环收缩压及阻力（－２．６％±７．４％～－１４．９％±７．０％、－１０．２％±６．８６％～－２１．１％±９．５３％）。腺苷剂量≥３００μｇ／（ｋｇ·ｍｉｎ）时心输出量、心搏指数有显著性增加。结论：腺苷具有最佳选择性肺循环扩血管作用的剂量范围在１００～２００μｇ／（ｋｇ·ｍｉｎ），是目前较理想的替代妥拉苏林的一种药物。
To investigate the dose-response relationship of adenosine’s vasodilator effect in hypoxic pulmonary hypertension, the hemodynamic changes of 8 hypoxic pulmonary hypertensive dogs were observed by intravenous infusion of adenosine. Results: Adenosine can significantly reduce body volume, pulmonary circulation pressure and systemic and pulmonary resistance in model dogs, and showed a negative correlation with dose (r = -0.970-0.994, P <0.05). Adenosine dose (100 ~ 200μg / (kg · min), the pulmonary systolic blood pressure and decreased the percentage of resistance (-11.0 ± 4.2% ~ -27.7 ± 14.8%, -18.8% ± 8.05% -29.8% ± 14.46%) was significantly higher than systolic blood pressure and resistance (-2.6% ± 7.4% -14.9% ± 7.0%, -10 .2% ± 6.86% ~ -21.1% ± 9.53%). Adenosine dose ≥ 300μg / (kg · min), cardiac output, cardiac index increased significantly. CONCLUSION: Adenosine has the best selective pulmonary vasodilator effect in the dose range of 100 ~ 200μg / (kg · min), which is an ideal substitute for tolathulin.