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肝动脉插管灌注化疗与栓塞治疗中晚期肝癌310例(560次)中,并发消化道出血13例,发生率占全组病例的4.19%。出血原因有:IC6例;肝功能损害,凝血机制差3例;化疗药对胃粘膜毒性作用和部分栓子误入胃供血动脉2例;食管静脉曲张破裂1例;肝肿瘤破裂1例。本文对消化道出血原因与防治方法进行了探讨,并建议在行肝动脉灌注化疗和栓塞治疗前采取肝功能估计和预防出血的方法,以减少因出血、肝衰及感染造成的死亡。
Hepatic Arterial Infusion Chemotherapy and Embolization In the treatment of 310 cases (560 cases) of advanced liver cancer, 13 cases of gastrointestinal hemorrhage were complicated, accounting for 4.19% of the total cases. Causes of bleeding: IC6 cases; liver damage, poor coagulation mechanism in 3 cases; chemotherapy drug gastric mucosal toxicity and partial embolism into the stomach feeding artery in 2 cases; esophageal varices rupture in 1 case; liver tumor rupture in 1 case. This article discusses the cause of gastrointestinal bleeding and its prevention and treatment methods, and suggests that hepatic arterial infusion chemotherapy and embolization should be used to estimate liver function and prevent bleeding before it is used to reduce the death caused by bleeding, liver failure and infection.