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白细胞-内皮间反应在缺血和再灌注损伤(I/R)引起的病变中具有重要作用,P-选择素(P-Selectin)是一种粘附分子,可能参与肝I/R时白细胞与内皮细胞之间的反应。取124雄性SD大鼠作实验研究以进一步阐明其作用。在全身麻醉下剖腹,于门静脉盲肠支与颈静脉之间建立一门体静脉分流,用血管夹阻断肝门,造成全肝缺血90分钟,然后关腹饲养。分成8组,第1组6只鼠作为正常对照;第2组16只鼠作为假手术组;第3组26只鼠作为全肝I/R对照
Leukocyte-endothelium responses play an important role in the pathological changes induced by ischemia and reperfusion injury (I / R). P-selectin is an adhesion molecule that may be involved in leukocyte and / The reaction between endothelial cells. 124 male SD rats were taken as experimental studies to further clarify its role. Cesarean section under general anesthesia was performed to establish a portal vein shunt between the portal vein cecum branch and the jugular vein. The portal vein was blocked with a vascular clamp, resulting in a complete hepatic ischemia for 90 minutes, followed by feeding in the abdomen. Divided into 8 groups, the first group of 6 rats as a normal control; the second group of 16 rats as a sham operation group; the third group of 26 rats as a whole liver I / R control