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采用原子吸收分光光度法测定了４０例宫颈癌，３０例子宫肌瘤组织和血清中Ｃｕ、Ｚｎ、Ｆｅ、Ｍｎ、Ｃａ和Ｓｒ的含量。结果表明，宫颈癌组织和血清中Ｃｕ、Ｆｅ含量和Ｃｕ／Ｚｎ比值明显高于非病变组织和健康人（Ｐ＜０．００１），而Ｚｎ、Ｃａ、Ｍｎ和Ｓｒ含量明显低于非病变组织，Ｚｎ、Ｃａ含量明显低于健康人血清（Ｐ＜０．０２～Ｐ＜０．００１）。子宫肌瘤组织中Ｆｅ含量和血清中Ｃｕ／Ｚｎ比值高于非病变组织和健康人血清（Ｐ＜０．００１），而组织中Ｚｎ和血清中Ｚｎ、Ｆｅ、Ｃａ含量明显低于非病变组织和健康人血清（Ｐ＜０．００１）。宫颈癌患者血清中Ｃｕ含量、Ｃｕ／Ｚｎ比值和癌组织中Ｃｕ／Ｚｎ明显高于肌瘤患者血清及肌瘤组织（Ｐ＜０．０１～Ｐ＜０．００１）。经ｌｏｇｉｓｔｉｃ多元逐步回归分析，血清中Ｃｕ含量较高者，发生宫颈癌的危险度较高，患者血清中Ｚｎ和组织Ｓｒ含量较高者，发生宫颈癌的危险度较低，Ｃｕ可能是诱发宫颈癌的危险因素。Ｚｎ、Ｓｒ可能是宫颈癌的保护因素。此外，血清中Ｃｕ／Ｚｎ比值测定对宫颈癌诊断阳性率为７２％，可作为宫颈癌诊断、鉴别指标之一。
The contents of Cu, Zn, Fe, Mn, Ca and Sr in 40 cases of cervical cancer, 30 cases of uterine fibroid tissue and serum were determined by atomic absorption spectrophotometry. The results showed that the contents of Cu, Fe and Cu / Zn in cervical cancer tissues and serum were significantly higher than those in non-diseased and healthy subjects (P <0.001), while the contents of Zn, Ca, Mn and Sr were significantly lower than those in non-diseased tissues , Zn and Ca contents were significantly lower than those in healthy volunteers (P <0.02 ~ P <0.001). The content of Fe and the ratio of Cu / Zn in serum of uterine fibroids were higher than that of non-diseased and healthy human serum (P <0.001), while the content of Zn, Fe and Ca in the tissues was significantly lower than that in non-diseased tissues And healthy human serum (P <0.001). Cu content, Cu / Zn ratio and Cu / Zn in cancer tissue of patients with cervical cancer were significantly higher than those in patients with leiomyoma (P <0.01 ~ P <0.001). By logistic multivariate stepwise regression analysis, the higher the content of Cu in serum, the higher the risk of developing cervical cancer, the higher the content of Zn and tissue Sr in serum of patients, the lower the risk of developing cervical cancer, and Cu may be the cause of cervical Cancer risk factors. Zn, Sr may be the protective factor of cervical cancer. In addition, the serum Cu / Zn ratio of the positive rate of diagnosis of cervical cancer was 72%, can be used as cervical cancer diagnosis, one of the indicators.