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目的探讨病毒感染所致的喘息性支气管炎患儿血清嗜酸性粒细胞趋化因子(Eotaxin)的监测及临床意义。方法 120例病毒感染所致的喘息性支气管炎患儿,将其按1年发作次数分为轻度喘息组(80例)和重度喘息组(40例),同时期健康体检儿童120例作为对照组,分析嗜酸性粒细胞趋化因子、单核细胞趋化蛋白-1(MCP-1)水平。结果轻度喘息组、重度喘息组与对照组Eotaxin、MCP-1水平比较均明显提高,差异有统计学意义(P<0.05);急性期Eotaxin、MCP-1水平与恢复期、临床痊愈期比较均明显上升,差异有统计学意义(P<0.05)。结论血清嗜酸性粒细胞趋化因子与气道高反应程度存在明显正相关性,喘息性支气管炎对血清嗜酸性粒细胞趋化因子进行检测可以确定疾病程度与临床分期,具有较高应用价值。
Objective To investigate the serum eosinophil chemotaxis (Eotaxin) in children with asthmatic bronchitis caused by viral infection and its clinical significance. Methods 120 children with asthmatic bronchitis caused by virus infection were divided into mild asthmatic group (n = 80) and severe asthmatic group (n = 40) according to the frequency of one-year attack. 120 healthy children Groups were analyzed for eotaxin, monocyte chemotactic protein-1 (MCP-1) levels. Results The levels of Eotaxin and MCP-1 in mild asthmatic group, severe asthmatic group and control group were significantly higher than those in control group (P <0.05). The levels of Eotaxin and MCP-1 in acute asthmatic group were significantly higher than those in recovery phase and clinical recuperation Were significantly increased, the difference was statistically significant (P <0.05). Conclusion Serum eosinophil chemokines and airway hyperresponsiveness there is a clear positive correlation, asthmatic bronchitis serum eosinophil chemokines can determine the degree of disease and clinical stage, has high value.