ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC1O) are not primary

• 作 者: Rishil J Kathawala Yi-Jun Wang
• 机 构: DepartmentofPharmaceuticalSciences,LaboratoryofCellBiology,DepartmentofBasicPharmaceuticalSciences
• 出 处: 癌症：英文版
• 发表日期: 2015年3期
• 关键词: ATP酶活性 阻力 家族 会员 亚科 HEK293 化疗药物 紫杉醇 ATP-binding cassette （ABC） transporters ATP-
• 基金项目: This work was supported by funds from the National Institutes of Health （TRISCA14370~） and St. John＇s University Research Seed Grant （579-7710-7002） to Dr. Zhe-Sheng Chert. Drs. Suneet Shukla and Sure

Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of