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为了解急性白血病（ＡＬ）早期死亡的高危因素，对近１０ａ上海地区２７家医院共３４７例ＡＬ住院患者早期死亡的高危因素进行了Ｌｏｇｉｓｔｉｃ回归分析。结果表明：出血、感染和多脏器衰竭是ＡＬ死亡的主要原因。全反式维甲酸的应用降低了急性早幼粒细胞白血病早期病死率，早期死亡的高危因素为：年龄≥６０岁或≤１岁，发病时伴有出血，弥散性毛细血管内凝血，肝脏明显肿大，ＦＡＢ分类属于急性骨髓细胞白血病，外周血细胞＞１００×１０９／Ｌ，ＢＰＣ＜５０×１０９／Ｌ，伴发病发热和感染。提示：为了降低ＡＬ的早期病死率，必须针对上述高危因素采取相应防治措施
In order to understand the risk factors for early death of acute leukemia (AL), Logistic regression analysis was performed on the high-risk factors of early death in 347 AL patients in 27 hospitals in Shanghai in the past 10 years. The results showed that bleeding, infection, and multiple organ failure were the main causes of AL death. The use of all-trans retinoic acid reduces the early mortality of acute promyelocytic leukemia. The risk factors for early death are: age ≥ 60 years or ≤ 1 year, accompanied by bleeding at the time of onset, disseminated intravascular coagulation, and marked liver Swollen, FAB classification belongs to acute myeloid leukemia, peripheral blood cells> 100 × 109 / L, BPC <50 × 109 / L, with fever and infection. Tip: In order to reduce the early mortality of AL, corresponding prevention measures must be taken for the above-mentioned high-risk factors.