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临床上癌症治疗所致的消化系统黏膜炎很常见,表现为伴或不伴腹泻的轻中度疼痛;有些可发展成溃疡,并导致全身感染和死亡,处理这些症状和后遗症使得资金和资源耗费明显增加,且目前可采取的预防和治疗措施有限。随着对消化系统黏膜炎复杂病理生物学的深入了解,现已促成了一系列颇有前景的新制剂的开发和试验,以及预防和治疗新范例的形成。
Digestive mucositis is clinically a common cause of cancer treatment, manifested as mild to moderate pain with or without diarrhea; some can develop ulcers and lead to systemic infections and deaths; handling these symptoms and sequelae can cost money and resources There has been a significant increase and there are currently limited preventive and curative measures available. With the in-depth understanding of the complex pathobiology of mucositis in the digestive system, a series of promising new agents have now been developed and tested, as well as the prevention and treatment of new paradigms.