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用 Ｈ Ｐ Ｌ Ｃ法测定米托蒽醌普通制剂和聚乳酸毫微粒靶向制剂兔耳静脉给药后经时血药浓度，并用３ Ｐ８７ 药动学模型计算其药动学参数，以此探讨并比较靶向制剂与普通制剂血药浓度的经时变化规律。结果显示：上述两种制剂兔血药时间曲线均符合三室模型，计算所得的理论药物浓度和实测药物浓度契合良好。靶向制剂改变了药物的吸收和消除过程，具有延效和缓释作用。
The pharmacokinetic parameters of mitoxantrone and polylactic acid nanoparticles targeting rabbit ear vein were determined by HPLC method and pharmacokinetic parameters were calculated by 3 P87 pharmacokinetic model The changes of plasma concentrations of targeted preparations and ordinary preparations over time were compared. The results showed that the blood time curves of the two preparations were in accordance with the three-compartment model, and the calculated theoretical drug concentration was in good agreement with the measured drug concentration. Targeted agents alter the absorption and elimination of drugs, with extended and sustained release.