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大蓟系菊科植物Cirsium japonicam DC.为多年生草本。对其降压作用研究结果如下: 一、降压药理试验1.实验材料:实验和临床用的大蓟是从南京附近山区采集加工的新鲜药材。(1)取鲜干根水煎液的浓缩液(1:1),静置,过滤,滤液调pH5～6,备用;(2)取鲜干根水煎液的浓缩液(1:1)调pH9～10,静置,过滤,滤液调pH5～6备用;(3)叶水煎液、叶碱液、全草水煎液、全草碱液,浓度均为1:1;(4)25%和50%酸性醇的鲜干根粗粉浸出液,浓度为1:2。2.方法及结果:实验动物为狗,以戊巴比妥钠(30mg/kg)作静注麻醉。用水银检压计连接于颈动脉记录血压,由股静脉给药,给药后一般观察
The Japanese geranium family, Cirsium japonicam DC, is a perennial herb. The results of the antihypertensive study are as follows: I. Antihypertensive pharmacological tests 1. Experimental materials: Experimental and clinical use of Otsuka is the collection of fresh herbs from the mountains near Nanjing. (1) Take a concentrated solution of fresh dried root decoction (1:1), stand, filter, adjust the pH of the filtrate to 5-6, and reserve; (2) Take a concentrated solution of fresh dry root decoction (1:1) Adjust the pH 9-10, stand, filter, adjust the pH of the filtrate to 5-6 standby; (3) leaf decoction, leaf lye, whole grass decoction, whole grass lye, the concentration is 1:1; (4) 25% and 50% of the fresh dried root extract of acidic alcohol powder, the concentration of 1:2. 2. Methods and results: The experimental animal was a dog, intravenous pentobarbital sodium (30mg/kg) for intravenous anesthesia. Blood pressure was connected to the carotid artery with a mercury pressure gauge, administered by the femoral vein, and generally observed after administration.