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将含有多西他赛、乙醇和壳聚糖的酏剂溶液经喷雾干燥制备多西他赛干酏剂(Delixir),并考察其外观形态、粒径、载药量、包封率及体外释药特性。扫描电镜观察表明,所得多西他赛干酏剂粉末外观较光滑、圆整,表面有圆形小突起,微粒间有一定黏连。本品平均粒径为76.8?m,载药量和包封率分别为(26.3±0.7)%和(78.9±2.2)%;2 h体外累积释放率为2.5%,12 h时为8%,而原药粉末分别为0.5%和2.7%。干酏剂有望成为提高水难溶性药物溶出速率的新型口服剂型。
The elixir solution containing docetaxel, ethanol and chitosan was spray-dried to prepare the docetaxel elixir (Delixir), and its appearance, particle size, drug loading, encapsulation efficiency and in vitro release Drug properties. Scanning electron microscopy showed that the resulting docetaxel dry elixir powder appearance is smooth, round, the surface of small round protrusions, particles have a certain adhesions. The average particle size of this product was 76.8 μm, the drug loading and entrapment efficiency were (26.3 ± 0.7)% and (78.9 ± 2.2)%, respectively. The cumulative release rate in vitro was 2.5% in 2 h and 8% The original powder were 0.5% and 2.7%. Anticoagulation is expected to be a new oral dosage form that improves the dissolution rate of poorly water-soluble drugs.