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本文报告1例口服盐酸四环素后引起食管溃疡。患者男性,24岁.既往无上消化道疾患及食管运动紊乱病史。因胸部感染,于凌晨1时吞服四环素250mg 后未饮水即就寝。于4时因上腹部及下段胸骨后剧烈疼痛醒来,饮水、喝牛奶及口服抗酸药物均无缓解,未再继续服用四环素片,亦未服其它药。8小时后仍有疼痛及吞咽痛而急诊.体检仅上腹有压痛。患者转到门诊,两天后上腹疼痛缓解,但仍有吞咽痛,未检出阳性体征。血红蛋白14.4g/dl,胸部 X线摄片正常。纤维内窥镜检查发现距门齿28cm 处的食管左侧壁有一局限性溃疡,溃疡上方与下方的食管粘膜及胃、十二指肠均正常。溃疡部位活组织检查为脓性肉芽组织,符合炎性溃疡。未经特殊治疗。3周后内窥镜复查,见溃疡已愈合,无狭窄形成。
This article reports 1 case of oral administration of tetracycline hydrochloride cause esophageal ulcers. Male patient, 24 years old. Past history of upper gastrointestinal disorders and esophageal motility disorders. Due to chest infection, in the morning 1 o’clock tetracycline swallowed 250mg after drinking without sleep. At 4:00 due to the upper abdomen and the lower part of the sternum after severe pain wake up, drinking water, drinking milk and oral anti-acid drugs were not relieved, did not continue to take tetracycline tablets, nor other drugs. 8 hours after the pain and swallowing pain and emergency. Physical examination only the upper abdomen with tenderness. The patient was transferred to the clinic. Two days later the pain in his abdomen was relieved. However, swallowing pain was still not detected and positive signs were not detected. Hemoglobin 14.4g / dl, chest X-ray normal. Fiber endoscopy found 28cm away from the incisors on the left side of the esophagus has a limited ulcer ulcer above and below the esophageal mucosa and stomach, duodenum were normal. Ulcer biopsy for purulent granulation tissue, in line with inflammatory ulcers. Without special treatment. Endoscopy after 3 weeks, see the ulcer has healed, no stenosis.