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目的研究急性脑梗死患者的神经元特异性烯醇化酶(NSE)、S100β蛋白血清含量变化与病情变化之间的关系.方法急性脑梗死患者于发病后12 h、24 h、48 h、10 d进行NSE,S100β蛋白水平测定,并与对照组40例健康人血清含量进行比较.结果脑梗死组NSE、S100β蛋白水平增高,与对照组比较有统计学差异(P<0.05).发病后48 h水平相对高值,发病初期100β蛋白水平与对照组比较无统计学意义(P>0.05).结论血清NSE、S100β蛋白测定可用于急性脑梗死病情监测,在临床中应予以重视.
Objective To study the relationship between the changes of serum NSE and S100β in patients with acute cerebral infarction and their changes.Methods The patients with acute cerebral infarction were divided into two groups at 12 h, 24 h, 48 h, 10 d The levels of NSE and S100β were measured and compared with that of the control group.Results The levels of NSE and S100β in the cerebral infarction group were significantly higher than those in the control group (P <0.05) (P> 0.05) .Conclusion The determination of serum NSE and S100β protein can be used to monitor the condition of acute cerebral infarction, which should be paid more attention in the clinic.