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目的:评估帕金森病(PD)患者中自主神经功能障碍症状发生比例、各症状分布的差异,及其与PD临床特点之间的关系。方法:应用SCOPA-AUT量表、统一帕金森病评分量表(UPDRS)、日常生活能力量表(ADL)、Hamilton抑郁量表和简易智能量表(MMSE)对116例原发性PD患者进行评估。结果:SCOPA-AUT总分和消化系统(GI)症状、排尿(UR)症状、体温调节(TH)症状、性功能(SX)症状评分均高于对照组,差异有极显著统计学意义(P=0.0001)。SCOPA-AUT总分与UPDRS评分、Hamilton抑郁量表评分呈正相关(P<0.001),与生活质量ADL评分呈负相关(P<0.001)。结论:自主神经功能障碍在PD早期就会出现,并随着疾病进展而加重,影响患者的生活质量。
OBJECTIVE: To evaluate the differences in the occurrence of symptoms of autonomic dysfunction and the distribution of symptoms among Parkinson’s disease (PD) patients and their relationship with the clinical features of PD. Methods: One hundred and sixty-six patients with primary PD underwent SCOPA-AUT, UPDRS, ADL, Hamilton Depression Scale and MMSE Evaluation. Results: The SCOPA-AUT score, GI symptom, UR symptom, TH and SX symptom scores were significantly higher than those of the control group (P = 0.0001). The total SCOPA-AUT score was positively correlated with the UPDRS score and the Hamilton Depression Scale score (P <0.001) and negatively with the quality of life ADL score (P <0.001). CONCLUSION: Autonomic dysfunction occurs early in PD and worsens as the disease progresses, affecting the patient’s quality of life.