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本文用~(125)I标记人Ⅲ型前胶原建立放射免疫分析法,并用此法测定100例正常人血清Ⅲ型前胶原(PCⅢ)(上限为120μg/L)及181例各种肝病和其他病人血清PCⅢ。肝病患者中肝硬化和慢性活动性肝炎显著升高;急性肝炎和原发性肝癌(单纯型)略有升高;慢性迁延性肝炎、胆石症和其他病人均无显著升高,37例患者肝活检纤维化程度和血清PCⅢ呈密切正相关(r=0.984,p<0.001)。结果说明此法测定血清PCⅢ诊断肝纤维化是有价值的。
Radioimmunoassay (RIA) was established by ~ (125) I labeling of human procollagen type Ⅲ, and the serum levels of type Ⅲ procollagen (PCⅢ) were measured in 100 healthy individuals (upper limit of 120 μg / L) and 181 cases of various liver diseases and other Patient serum PC Ⅲ. Liver cirrhosis and chronic active hepatitis were significantly increased in patients with acute hepatitis and primary liver cancer (simple type) increased slightly; chronic persistent hepatitis, cholelithiasis and other patients were no significant increase in 37 patients with liver The degree of biopsy fibrosis was positively correlated with serum PCⅢ (r = 0.984, p <0.001). The results show that this method for the determination of serum PCⅢ diagnosis of liver fibrosis is valuable.