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目的:探讨血浆D-二聚体在肝癌临床分期、分级中的临床意义。方法:免疫比浊法检测54例不同临床分期及Edmondson病理分级肝癌患者(肝癌组)、同期健康体检者34例(对照组)血浆D-二聚体水平,并进行比较。结果:肝癌组血浆D-二聚体水平高于对照组(P<0.05);随着临床分期增高,肝癌组D-二聚体水平逐渐升高,各分期间比较差异均有统计学意义(P<0.05);各病理分级间血浆D-二聚体水平比较差异无统计学意义(P>0.05)。结论:血浆D-二聚体水平与肝癌临床分期密切相关,与肝癌Edmondson病理分级无相关性。动态观察肝癌患者血清D-二聚体水平对肝癌的分期及病情判断有重要临床意义。
Objective: To investigate the clinical significance of plasma D-dimer in the clinical staging and grading of liver cancer. Methods: Plasma D-dimer levels in 54 cases of liver cancer patients with different clinical stages and Edmondson histological grades (hepatoma group) and 34 healthy controls (control group) were determined by immunonephelometry. Results: The plasma D-dimer level in HCC group was higher than that in control group (P<0.05). With the increase of clinical stage, the D-dimer level in liver cancer group gradually increased, and there was a statistically significant difference between each phase. P<0.05); There was no significant difference in plasma D-dimer levels between pathological grades (P>0.05). Conclusion: Plasma D-dimer level is closely related to the clinical stage of liver cancer, and has no correlation with Edmondson pathological grade of liver cancer. Dynamic observation of serum D-dimer levels in patients with hepatocellular carcinoma has important clinical significance for the staging of liver cancer and judgment of disease.