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目的研究绝经后脆性骨折患者血清转铁蛋白与骨代谢指标的关系。方法检测190例绝经后髋部脆性骨折患者的血清转铁蛋白、Ⅰ型前胶原氨基端延长肽(PINP)、Ⅰ型胶原C端肽β降解产物(β-CTX)、25羟维生素D3[25(OH)D3]及相关生化指标,分析转铁蛋白与骨代谢指标的相关性。结果绝经后髋部脆性骨折患者存在血清转铁蛋白和25(OH)D3水平降低;转铁蛋白降低患者的血清25(OH)D3和钙水平均低于转铁蛋白正常患者(P<0.01)。血清转铁蛋白与β-CTX呈负相关(r=-0.20,P<0.01),与25(OH)D3和钙转铁蛋白呈正相关(r=0.23和r=0.27,P<0.01),而与PINP和磷未见明显相关性(r=-0.01和0.06,P>0.05)。结论绝经后脆性骨折患者常存在铁蓄积状态;这与骨代谢水平密切相关。
Objective To study the relationship between serum transferrin and bone metabolic index in postmenopausal women with brittle fracture. Methods The serum levels of transferrin, type Ⅰ procollagen aminoterminal extension peptide (PINP), type Ⅰ collagen β-terminal beta-degradation product (β-CTX) and 25-hydroxyvitamin D3 were measured in 190 postmenopausal women with hip fracture (OH) D3] and related biochemical indicators, analysis of transferrin and bone metabolism indicators. Results Serum transferrin and 25 (OH) D3 levels were decreased in patients with postbronchial hip fracture. Serum 25 (OH) D3 and calcium levels were lower in patients with transferrin than those in normal transferrin patients (P <0.01) . Serum transferrin was negatively correlated with β-CTX (r = -0.20, P <0.01) and positively correlated with 25 (OH) D3 and calcium transferrin (r = 0.23 and r = 0.27, P <0.01) There was no significant correlation between PINP and phosphorus (r = -0.01 and 0.06, P> 0.05). Conclusions Fecal occlusion often exists in patients with postmenopausal fracture; this is closely related to the level of bone metabolism.