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脂肪的过度沉积会引发多种疾病,如心脏病、高血压、高甘油三酯血症、Ⅱ型糖尿病等。小白鼠(Mus musculus)和猪(Sus domesticus)是常用的研究脂肪沉积的模式动物,近年来随着研究的深入,发现脂肪代谢调控网络错综复杂,调控因子相互作用。秀丽隐杆线虫(Caenorhabditis elegans)具有结构简单、身体透明、便于观察、繁殖周期短、易于人工培养等特征,因此使得秀丽隐杆线虫进行脂肪调控的研究成为了可能。本文通过总结国内外线虫脂肪沉积方面的研究,综述秀丽隐杆线虫研究脂肪沉积的进展。
Over-deposition of fat can trigger a variety of diseases, such as heart disease, high blood pressure, hypertriglyceridemia, type II diabetes and so on. Mus musculus and swine (Sus domesticus) are common animal models of fat deposition. In recent years, with the deepening of researches, it has been found that the network of fat metabolism is complex and regulators interact with each other. Caenorhabditis elegans has the characteristics of simple structure, transparent body, easy observation, short reproductive cycle and easy artificial cultivation. Therefore, it is possible for Caenorhabditis elegans to study fat regulation. This review summarizes the studies on fat deposition in nematode at home and abroad and reviews the progress of fat deposition in C. elegans.