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目的 :探讨血管紧张素转换酶 (ACE)基因多态性及血管紧张素Ⅱ (AⅡ )活性在阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)患者高血压发病中的作用。方法 :应用聚合酶链反应 ,对 30例OSAHS并发高血压患者 (OSAHS并发高血压组 ) ,30例血压正常的OSAHS患者 (OSAHS血压正常组 )ACE基因插入 /缺失 (I/D)多态性和等位基因的分布频率进行检测。以 30例健康体检者为正常对照组。同时测定其血清AⅡ含量。结果 :OSAHS并发高血压组与OSAHS血压正常组及正常对照组比较 ,ACE基因II基因型明显增高 (P <0 .0 5和P <0 .0 1) ,I等位基因出现频率也明显增高 (均P <0 .0 1) ;OSAHS血压正常组与正常对照组比较 ,ACE基因多态性及I等位基因出现频率差异无统计学意义 (均P >0 .0 5 )。OSAHS并发高血压组及OSAHS血压正常组血清AⅡ含量分别为 (10 9.83± 2 3.72 )和 (10 9.5 0± 2 7.6 5 )ng/L ,其差异无统计学意义 (P >0 .0 5 ) ;分别与正常对照组 [(90 .5 7± 16 .35 )ng/L]比较 ,差异有统计学意义 (均P <0 .0 1)。结论 :ACE基因I等位基因和II基因型频率增加是OSAHS并发高血压发病的重要危险因素 ,说明遗传因素是影响OSAHS发生高血压的重要因素之一。OSAHS患者血清AⅡ含量明显增高 ,可能与OSAHS的昼夜血压变化有关 ,但在OSAHS并发高?
Objective: To investigate the role of angiotensin converting enzyme (ACE) gene polymorphism and angiotensin Ⅱ (AⅡ) activity in the pathogenesis of hypertension in obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: Polymerase chain reaction (PCR) was used to detect ACE gene insertion / deletion (I / D) polymorphisms in 30 patients with OSAHS complicated with hypertension (OSAHS complicated with hypertension) and 30 patients with normotensive OSAHS (OSAHS normalized) And allele frequency distribution of the test. 30 healthy people as normal control group. Simultaneous determination of serum A Ⅱ content. Results: The genotype II of ACE gene was significantly higher in patients with OSAHS complicated with OSAHS and normal control group (P <0.05 and P <0.01), and the frequency of I allele was also significantly higher (All P <0.01). There was no significant difference in ACE gene polymorphism and I allele between OSAHS normotensive group and normal control group (all P> 0.05). The serum levels of AⅡ in patients with OSAHS complicated with hypertension and those with OSAHS were (10 9.83 ± 2. 3.72) and (10 9.5 0 ± 2 7.6 5) ng / L, respectively, with no significant difference (P> 0.05) ; Compared with the normal control group [(90.57 ± 16.35) ng / L], the difference was statistically significant (all P <0.01). Conclusion: The increased frequency of ACE gene I and II genotypes is an important risk factor for OSAHS complicated with hypertension, indicating that genetic factors are one of the important factors that affect the occurrence of hypertension in OSAHS. OSAHS serum A Ⅱ levels were significantly higher, may be related to OSAHS diurnal blood pressure changes, but in patients with OSAHS complicated by high?