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【目的】探讨卵巢浆液性癌的MDACC分级及临床病理意义。【方法】回顾性分析本院63例卵巢浆液性癌患者的病理资料,对其进行MDACC分级及传统 WHO分级对比,所有患者行 p53蛋白免疫组化染色,总结其临床病理特点并比较两种分级的优缺点。【方法】MDACC分级法中低级别相当于传统 WHO分级法中的Ⅰ级,高级别组相当于Ⅱ级和Ⅲ级；MDACC分级中低级别组与高级别组患者的平均年龄、平均肿瘤直径、发生范围比较差异无统计学意义(P >0.05)；MDACC分级中高级别组的癌症患者临床分期更高,无病生存时间及生存时间明显短于低级别组,5年生存例数少于低级别组,p53蛋白突变型表达更多,差异均具有统计学意义(P 0.05).In MDACC grading,clinical stage of cancer patients of high level group was higher,no disease survival duration and survival time was significantly shorter than those in the low grade group,and 5-year survival of patients was less than the number of low-level group,with more p5 3 mutant expression,the difference has statistical significance (P <0.05).[Conclusion]MDACC classification has a very good fit with molecular biological phenotype and patho-genesis theory,it is simple and easy to grasp,and has a certain guiding significance for the prognosis.