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目的 探讨脑梗死患者发病后血清白细胞介素 6 (IL 6 )和转化生长因子 β1(TGB β1)的变化特点及其意义。方法 采用双抗体夹心酶联免疫吸附试验 (ELISA)法对 31例脑梗死患者血清IL 6和TGF β1进行动态检测。结果 脑梗死患者血清IL 6在发病后第 1天升至最高 [(4 8.4± 10 .4)ng/L],随后逐渐下降 ,第 3天和第7天分别下降至 (38.2± 9.6 )ng/L和 (31.4± 6 .8)ng/L ,第 7天仍显著高于对照组 [(2 3.7± 5 .9)ng/L ,P <0 .0 1]。轻、中、重三型脑梗死组间在同一时间段差异无显著性 (P >0 .0 5 )。在不同大小梗死灶间除发病后第 1天组间差异有显著性外 (F =4.13,P <0 .0 5 ) ,其它时间段差异无显著性 (P >0 .0 5 ) ,其峰值与病情轻重无关 (rs=0 .186 ,P >0 .0 5 ) ,而其与梗死灶大小呈正相关 (rs=0 .5 0 8,P <0 .0 1) ;脑梗死患者血清TGF β1在发病后第 1天为最低 ,随后渐升 ,至第 7天接近对照组 [(4 2 .1± 8.2 ) μg/L],其变化与病情轻重或梗死灶大小无显著相关 (P>0 .0 5 )。结论 结果提示 :IL 6和TGF β1可能都参与了脑梗死的免疫 炎症反应 ;动态检测IL 6和TGF β1有助于脑梗死的病情监测和治疗
Objective To investigate the characteristics and significance of serum interleukin 6 (IL 6) and transforming growth factor β 1 (TGB β 1) in patients with cerebral infarction. Methods Serum levels of IL-6 and TGF-β1 in 31 patients with cerebral infarction were detected by ELISA. Results Serum IL-6 in patients with cerebral infarction increased to the highest at day 1 [(8.4 ± 10.4) ng / L], then gradually decreased and decreased to (38.2 ± 9.6) ng on day 3 and 7 / L and (31.4 ± 6. 8) ng / L respectively, and still significantly higher on the 7th day than the control group [(2 3.7 ± 5.9) ng / L, P <0.01]. Light, moderate and severe cerebral infarction group at the same time interval was no significant difference (P> 0.05). There was no significant difference between the two groups (F = 4.13, P <0.05) except for the first day after onset of infarction. There was no significant difference at other time points (P> 0.05) (Rs = 0.186, P> 0.05), but it was positively correlated with the size of infarction (rs = 0.508, P <0.01). Serum TGFβ1 The first day after onset was the lowest, then gradually increased, and close to the control group on the seventh day [(42.1 ± 8.2) μg / L], with no significant correlation with the severity of the disease or infarct size (P> 0 .0 5). Conclusion The results suggest that both IL 6 and TGF β1 may be involved in the immune inflammatory response of cerebral infarction. Dynamic detection of IL 6 and TGF β 1 may be helpful for the monitoring and treatment of cerebral infarction