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目的评价他扎罗汀凝胶联合酞丁安搽剂治疗面部扁平疣的临床疗效和安全性。方法将入选的90例面部扁平疣患者随机分为3组,各30例。治疗组:他扎罗汀凝胶联合酞丁安搽剂治疗;对照1组:单用他扎罗汀凝胶治疗;对照2组:单用酞丁安搽剂治疗。3组患者的疗程均为8周,分别在治疗2,4,6和8周末时观察疗效及不良反应,并在治疗前后查血、尿常规和肝肾功能。结果治疗结束后,治疗组有效率(86.67%)显著高于对照1组(53.33%)和对照2组(53.33%),差异有统计学意义(P<0.05)。3组间均有个别病例出现轻微不良反应,但均可耐受。结论他扎罗汀凝胶联合应用酞丁安搽剂治疗面部扁平疣治疗扁平疣疗效确切,优于两药分别单用组的临床疗效。
Objective To evaluate the clinical efficacy and safety of tazarotene gel combined with Phthalide Dingan liniment in the treatment of facial flat warts. Methods The 90 patients with facial flat warts were randomly divided into 3 groups, 30 cases each. The treatment group: tazarotene gel combined with phthalocyanine Dingan liniment treatment; control group 1: tazarotene gel alone; control group 2: single phthalocinan liniment treatment. Three groups of patients were treated for 8 weeks, respectively, in the treatment of 2,4,6 and 8 weekend to observe the efficacy and adverse reactions, and check the blood before and after treatment, urine and liver and kidney function. Results After the treatment, the effective rate (86.67%) in the treatment group was significantly higher than that in the control group 1 (53.33%) and the control group 2 (53.33%), with significant difference (P <0.05). There were mild adverse reactions in individual cases among the 3 groups, but both were tolerated. Conclusion Tazarotene gel combined with phthalocyanine Dingan liniment for the treatment of flat wart facial flat warts curative effect is better than the two groups of single-use curative effect.