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亲环素A(cyclophilin A,CyPA)是一种在生物界广泛存在、高度保守的蛋白质,最初作为环孢素A(cyclosporin A,CsA)的细胞受体被发现。CyPA具有肽酰脯氨酰顺反异构酶(PPIase),在细胞内与CsA结合,介导免疫抑制
Cyclophilin A (CyPA) is a kind of protein widely existed in the biological world and highly conserved. It was originally discovered as a cell receptor of cyclosporin A (CsA). CyPA has peptidyl prolyl cis-trans isomerase (PPIase), which binds CsA intracellularly and mediates immunosuppression