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目的了解艾滋病患者治疗前后CD4~+/CD8~+比值变化情况及治疗前CD4~+/CD8~+比值对治疗时机选择的影响。方法对2006-2015年在顺德区接受抗病毒治疗的艾滋病患者治疗前后CD4~+/CD8~+比值及治疗前CD4~+/CD8~+比值与治疗后CD4~+T淋巴细胞数变化关系进行统计学分析。结果治疗后CD4~+/CD8~+比值表现为随治疗时间延长而不断增大,但增幅在减小;初始治疗年龄以及性别不影响CD4~+/CD8~+比值的变化(P>0.05);治疗前CD4~+/CD8~+比值<0.2与≥0.3的艾滋病患者相比,其治疗后CD4~+T淋巴细胞数差异有统计学意义(P<0.05),后者治疗后CD4~+T淋巴细胞数增长更明显。结论抗病毒治疗能有效提高CD4~+/CD8~+比值,但需保证治疗依从性;早期治疗效果更好,对于治疗前CD4~+/CD8~+比值<0.2的艾滋病患者应积极动员其开始抗病毒治疗。
Objective To understand the changes of CD4 ~ + / CD8 ~ + ratio before and after treatment and the effect of CD4 ~ + / CD8 ~ + ratio before treatment on the timing of treatment. Methods The relationship between CD4 ~ + / CD8 ~ + ratio and CD4 ~ + / CD8 ~ + ratio before and after treatment of AIDS patients receiving antiviral therapy in Shunde District from 2006 to 2015 was compared with that of CD4 ~ + T lymphocytes after treatment Statistical analysis. Results The ratio of CD4 ~ + / CD8 ~ + increased with the prolongation of treatment time after treatment, but the increase decreased. The initial treatment age and sex did not affect the change of CD4 ~ + / CD8 ~ + ratio (P> 0.05) ; CD4 ~ + T lymphocyte count after treatment had significant difference (P <0.05) compared with AIDS patients with CD4 ~ + / CD8 ~ + ratio <0.2 and ≥0.3 before treatment, T lymphocytes increased more significantly. Conclusions Antiviral therapy can effectively increase the ratio of CD4 ~ + / CD8 ~ +, but it is necessary to ensure compliance with treatment. Early treatment is better, and AIDS patients with CD4 ~ + / CD8 ~ + ratio <0.2 before treatment should be actively mobilized Antiviral treatment.