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目的探讨病情稳定的类风湿关节炎(rheumatoid arthritis,RA)患者临床症状与天气指标变化的相关性。方法选择合肥地区64例病情稳定的RA患者,采用问卷调查方式每天记录患者的关节症状和整体评估。同时收集每天气象指标。采用线性混合模型分析气象指标与RA患者临床症状的相关性。结果 RA患者关节压痛数与大气压、露点温度呈负相关(r1=-0.007,P1=0.022;r2=-0.049,P2=0.016),与相对湿度、日最高温度呈正相关(r1=0.010,P1=0.035;r2=0.026,P2<0.001)。关节肿胀数与日最低温度呈正相关(r1=0.008,P1=0.007),与水汽压、低云量、日降水量呈负相关(均有P<0.05)。晨僵持续时间与日总云量和降水量呈正相关(r1=0.065,P1<0.001;r2=0.004,P2=0.016)。休息痛与大气压呈负相关(r1=-0.006,P1=0.041),与日最高温度、总云量和降水量呈正相关(均有P<0.05)。患者整体评估与相对湿度、日平均温度呈正相关(r1=0.018,P1<0.001;r2=0.064,P2=0.005),与日最低温度、露点温度和日照总时数呈负相关(均有P<0.05)。结论病情稳定的RA患者临床症状受天气变化影响。
Objective To investigate the correlation between clinical symptoms and the changes of weather indexes in patients with stable rheumatoid arthritis (RA). Methods Sixty-four patients with stable RA in Hefei were enrolled in this study. Symptoms and overall assessment of the patients were recorded daily by questionnaire. At the same time collect daily meteorological indicators. The linear mixed model was used to analyze the correlation between meteorological indexes and clinical symptoms of RA patients. Results The joint pressure of RA patients was negatively correlated with the atmospheric pressure and dew point temperature (r1 = -0.007, P1 = 0.022; r2 = -0.049, P2 = 0.016) and positively correlated with relative humidity and daily maximum temperature (r1 = 0.035; r2 = 0.026, P2 <0.001). There was a positive correlation between swollen joint number and daily minimum temperature (r1 = 0.008, P1 = 0.007), negatively correlated with vapor pressure, low cloud cover and daily precipitation (P <0.05). The duration of morning stiffness was positively correlated with the total daily cloud amount and precipitation (r1 = 0.065, P1 <0.001; r2 = 0.004, P2 = 0.016). The rest pain was negatively correlated with the atmospheric pressure (r1 = -0.006, P1 = 0.041), and positively correlated with the maximum daily temperature, total cloud amount and precipitation (both P <0.05). The patients’ overall assessment was positively correlated with relative humidity and daily average temperature (r1 = 0.018, P1.001; r2 = 0.064, P2 = 0.005), and negatively correlated with daily minimum temperature, dew point temperature and total sunshine hours (P < 0.05). Conclusion The clinical symptoms of patients with stable RA are affected by the changes of the weather.