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本文选用小鼠睾丸生殖细胞染色体畸变分析试验，和大国发育毒性试验，对萘丁美酮的生殖毒性进行了研究，小鼠睾丸生殖细胞染色体分析试验设三个剂量组：１６７９、８４８．５、４２１，２５１ｍｇ／ｋｇ；和溶剂对照组。连续灌胃染毒５天，第六天取样分析。精原细胞染色体畸变细胞率、间隙率，初级精母细胞第一次减数分裂中期相的畸变细胞率和染色体早＊分离军，以及多倍体细胞率，与熔剂对照组相比较均无显著性差异，ＳＤ大凤的发育毒性试验设三个剂量组：２５０、６２．５和１５．６２５ｍｇ／ｋｇ，和一个敌枯双（１．６ｍｇ／ｋｇ）阳性对照组。分别于妊娠第７—１３天每日空腹灌胃染毒一次，并于妊娠第３、６、９、１２、１５．１８、２０和２１天称体重调整灌胃量，第２１天剖杀孕鼠取胎，观察并记录：孕鼠增重，死胎数，活胎数，胎重，胎鼠外观、内脏及骨骼畸形，以及胎鼠骨骼发育。结果表明：萘丁美酮对孕鼠增重，胎仔发育，胚胎及胎仔存活，胎仔骨骼发育均无影响；也未见引起胎鼠外观、内脏和骨骼畸形。本研究表明，萘丁美酮对雌性小鼠生殖细胞无遗传毒性，对大鼠胚胎及胎仔无发育毒性。
In this paper, the test of germ cell chromosome aberration in testis and the developmental toxicity test in large countries were used to study the reproductive toxicity of nabumetone. The test of germ cell chromosome in mice was established in three dose groups: 1679, 848.5, 421, 251 mg / kg; and solvent control. Continuous gavage for 5 days, sampling analysis on the sixth day. The aberrant cell ratio, the gap percentage, the aberrant cell rate of the first stage of meiosis cells, the early chromosome separation of the spermatogonia, and the rate of polyploidy cells in spermatogonia showed no significant difference compared with the flux control group Sex differences, SD Dafeng developmental toxicity test set three dose groups: 250,62.5 and 15.625mg / kg, and a double doubly (1.6mg / kg) positive control group. Respectively, in the first 7th day of gestation, fasting gavage once a day, and on the 3rd, 6th, 9th, 12th, 15th, 18th and 20th day of gestation, The rats were removed from the fetus, observed and recorded: weight gain of pregnant rats, the number of stillbirths, live births, fetal weight, fetal rat appearance, visceral and skeletal deformities, and fetal rat skeletal development. The results showed that nabumetone had no effect on pregnant rats’ weight gain, fetal development, embryo and fetal survival, fetal bone development, nor fetal appearance, visceral and skeletal deformity. This study shows that nabumetone genotoxicity of female mice genotoxicity, no developmental toxicity on rat embryos and fetal.