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经由大鼠、小鼠甩尾及兔甩头法测痛,证实k_3具有剂量依赖的镇痛作用。兔侧脑室微量注射k_3亦有显著镇痛效应。k_3的镇痛作用可被阿片拮抗剂纳络酮所拮抗。实验观察到k_3与吗啡的镇痛效应间存在交叉耐受现象。一定浓度的k_3可抑制电场刺激所致豚鼠回肠纵肌标本的收缩,这一效应亦可被纳络酮部分逆转。小鼠经k_3预处理后对k_3的镇痛产生耐受;连续k_3大剂量预处理后纳络酮激发不产生跳跃。
Through the rat, mouse tail flick and rabbit head shaking method to test the pain, confirmed that k_3 has a dose-dependent analgesic effect. Rabbit lateral ventricle microinjection of k_3 also had significant analgesic effect. The analgesic effect of k_3 can be antagonized by the opioid antagonist naloxone. Cross-tolerance was observed between the analgesic effect of k_3 and morphine. A certain concentration of k_3 can inhibit the contraction of longitudinal muscle of guinea pig ileum induced by electric field stimulation. This effect can also be partially reversed by naloxone. The mice were tolerated by k_3 pretreatment to k_3 analgesia. No stimulation was found after n_4 administration was pretreated with large doses of k_3.