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The NLRP3 inflammasome,which consists of the NLRP3(nucleotide-binding oligomerization domain(Nod)–like receptor 3)scaffold,the ASC(apoptosis-associated speck-like protein containing a CARD)adaptor and procaspase-1,is assembled after the cytoplasmic LRRs(leucine-rich repeats)of NLRP3 sense pathogens or danger signals.The NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1.Caspase-1in turn regulates the maturation of the proinflammasome cytokines IL-1βand IL-18,which leads to an inflammatory response.The inflammasome plays an important role in the development of Alzheimer’s disease and bacterial meningitis,and the NLRP3 inflammasome may become a new target for the prevention and treatment of central nervous system diseases.
The NLRP3 inflammasome, which consists of the NLRP3 (nucleotide-binding oligomerization domain (Nod) -like receptor 3) scaffold, the ASC (apoptosis-associated speck-like protein containing a CARD) adapter and procaspase-1, is assembled after the cytoplasmic LRRs (leucine-rich repeats) of NLRP3 sense pathogens or danger signals. NLRP3 inflammasome controls the activation of the proteolytic enzyme caspase-1. Caspase-1 in turn regulates the maturation of the proinflammasome cytokines IL-1 beta and IL-18, which leads to an inflammatory response. inflammasome plays an important role in the development of Alzheimer’s disease and bacterial meningitis, and the NLRP3 inflammasome may a new target for the prevention and treatment of central nervous system diseases.