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青微素经口应用的效力早已是确定无疑了.但在某些情况下口腔粘膜对青微素却极为敏感。青微素(及链微素)能引起多种多样的过敏性表现(荨麻疹、剥脱性皮炎).当“含服”青微素锭及其他方式的局部应用时,则口腔粘膜上的这些反应尤为明显,此时可能发生特异性的剥脱性舌炎。舌背的丝状乳头全部或部分消失,而变得平滑、发红,宛如被烧灼过似的.舌尖亦常被侵及、呈现持久性疼痛,而这种疼痛并不经常决定于舌部病变的部位及面积。这些现象都可统称为“青微素舌”。
The efficacy of oral administration of procyanidins has long been known, but in some cases the oral mucosa is extremely sensitive to procyanidins. While nuclides (and streptomycin) cause a wide variety of allergic manifestations (urticaria, exfoliative dermatitis), these “oral” nuclides and other forms of topical application The reaction is particularly pronounced, when exfoliative glossitis may occur at this time. Fibular nipples on the tongue's back disappear in whole or in part and become smooth and red, as if burned. Tongue tips are also frequently invaded and present persistent pain that does not often depend on the tongue The area and area. These phenomena can be collectively referred to as “green tongue tongue.”